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Scientific publications

Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy.

Borot F, Humbert O, Ehmsen JT, Fields E, Kohli S, Radtke S, Swing K, Pande D, Enstrom MR, Laszlo GS, Mayuranathan T, Ali AM, Weiss MJ, Yen JS, Newby GA, Walter RB, Liu DR, Mukherjee S, Kiem HP.Nat Commun. 2025 May 27;16(1):4899. doi: 10.1038/s41467-025-59713-2.PMID: 40425554 

Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis.

Ng JQ, Jafarov TH, Little CB, Wang T, Ali AM, Ma Y, Radford GA, Vrbanac L, Ichinose M, Whittle S, Hunter DJ, Lannagan TRM, Suzuki N, Goyne JM, Kobayashi H, Wang TC, Haynes DR, Menicanin D, Gronthos S, Worthley DL, Woods SL, Mukherjee S.Nat Commun. 2023 Oct 31;14(1):6909. doi: 10.1038/s41467-023-42199-1.PMID: 37907525

A novel therapeutic bispecific format based on synthetic orthogonal heterodimers enables T cell activity against Acute myeloid leukemia.

Burke A, Borot F, Du X, Churchill M, Ding J, Grass AM, DeSouza P, Ali AM, Mukherjee S.Oncogene. 2023 Jan;42(1):26-34. doi: 10.1038/s41388-022-02532-2. Epub 2022 Nov 10.PMID: 36357573

SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes.

Lieu YK, Liu Z, Ali AM, Wei X, Penson A, Zhang J, An X, Rabadan R, Raza A, Manley JL, Mukherjee S.Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2111703119. doi: 10.1073/pnas.2111703119.PMID: 34930825

Before Virus, After Virus: A Reckoning.

Mukherjee S.Cell. 2020 Oct 15;183(2):308-314. doi: 10.1016/j.cell.2020.09.042.PMID: 33064987

Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1.

Zhang J, Ali AM, Lieu YK, Liu Z, Gao J, Rabadan R, Raza A, Mukherjee S, Manley JL.Mol Cell. 2019 Oct 3;76(1):82-95.e7. doi: 10.1016/j.molcel.2019.07.017. Epub 2019 Aug 29.PMID: 31474574

Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies.

Borot F, Wang H, Ma Y, Jafarov T, Raza A, Ali AM, Mukherjee S.Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11978-11987. doi: 10.1073/pnas.1819992116. Epub 2019 May 28.PMID: 31138698

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

​Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, Rubin MA, Mukherjee S, Cantley LC.Nature. 2018 Aug;560(7719):499-503. doi: 10.1038/s41586-018-0343-4. Epub 2018 Jul 4.PMID: 30051890

Cancer, Our Genes, And The Anxiety Of Risk-Based Medicine.

Mukherjee S.Health Aff (Millwood). 2018 May;37(5):817-820. doi: 10.1377/hlthaff.2018.0344.PMID: 29733715

Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop.

Chen X, Deng H, Churchill MJ, Luchsinger LL, Du X, Chu TH, Friedman RA, Middelhoff M, Ding H, Tailor YH, Wang ALE, Liu H, Niu Z, Wang H, Jiang Z, Renders S, Ho SH, Shah SV, Tishchenko P, Chang W, Swayne TC, Munteanu L, Califano A, Takahashi R, Nagar KK, Renz BW, Worthley DL, Westphalen CB, Hayakawa Y, Asfaha S, Borot F, Lin CS, Snoeck HW, Mukherjee S, Wang TC.Cell Stem Cell. 2017 Dec 7;21(6):747-760.e7. doi: 10.1016/j.stem.2017.11.003. Epub 2017 Nov 30.PMID: 29198940

Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities.

Zhang J, Lieu YK, Ali AM, Penson A, Reggio KS, Rabadan R, Raza A, Mukherjee S, Manley JL.Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4726-34. doi: 10.1073/pnas.1514105112. Epub 2015 Aug 10.PMID: 26261309

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC.Cell. 2015 Jan 15;160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042.PMID: 25594183

Siddhartha mukherjee

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